(S,R,S)-AHPC-PEG2-NH2 hydrochloride( VH032-PEG2-NH2 hydrochloride | VHL Ligand-Linker Conjugates 3 hydrochloride | E3 ligase Ligand-Linker Conjugates 6 )

Catalog No. M26952 CAS No. 2097973-72-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

(S,R,S)-AHPC-PEG2-NH2 hydrochloride
Note

Research use only, not for human use.
Brief Description

(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
Description

(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vivo

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Synonyms

VH032-PEG2-NH2 hydrochloride | VHL Ligand-Linker Conjugates 3 hydrochloride | E3 ligase Ligand-Linker Conjugates 6
Pathway

Others
Target

Other Targets
Recptor

5-HT7
Research Area

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Indication

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CAS Number

2097973-72-1
Formula Weight

612.18
Molecular Formula

C28H42ClN5O6S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 150 mg/mL (245.03 mM)
SMILES

O=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
Chemical Name

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1.Guscott MR, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003;44(8):1031-1037.

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